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Hiroki Yokota, Ph.D.: The Systems Biology of the Skeletal System



Hiroki Yokota will introduce his recent systems biology research on mineral metabolism and bone remodeling by focusing on calcium/phosphate regulation. It is well known that the level of phosphorus in plasma for healthy individuals is kept nearly constant by parathyroid hormone and vitamin D. However, the recent discovery of fibroblast growth factor 23 as a key circulating factor for phosphate and vitamin D metabolism requires a quantitative reevaluation of the regulatory mechanism. Furthermore, about 90% of the total phosphorus in the adult human body is in the form of calcium crystals in the bones, and thus phosphate metabolism is closely linked to bone remodeling. Dr. Yokota will discuss the usage of genome-wide expression data and potential applications of control theories.


Dr. Hiroki Yokota is Professor of Biomedical Engineering, Mechanical Engineering (adjunct), and Anatomy and Cell Biology (adjunct) at IUPUI. He received his PhD in astronautics from the University of Tokyo in 1983, and a second PhD in molecular, cellular, and developmental biology from Indiana University, Bloomington, in 1993. He has been engaged in musculoskeletal research using cell culture and animals with an emphasis on biomechanics, bone remodeling, and fracture healing. He is a Fellow of American Institute for Medical and Biological Engineering.