Xiaowen Liu, Ph.D.

Xiaowen Liu
  • Associate Professor, Bioinformatics


xwliuiupui [dot] edu
IT 479


  • Ph.D., Computer Science, City University of Hong Kong (2008)
  • M.Eng., Computer Science, Shandong University, China (2004)
  • B.S., Computer Science, Shandong University, China (1996)


Xiaowen Liu is an associate professor of bioinformatics in the Department of BioHealth Informatics. Before joining SOIC, he worked as a postdoctoral fellow at the University of Western Ontario, the University of Waterloo, and the University of California, San Diego, from 2008 to 2012.

Liu’s research focuses on computational proteomics, especially mass spectrometry-based top-down proteomics, which is capable of identifying various proteoforms in biological samples. Liu’s lab has developed powerful software tools for top-down mass spectrometry-based proteoform identification, characterization, and quantitation. These efficient software tools, including TopFD, TopPIC and TopMG, have been widely used in the proteomics community. They significantly facilitate the application of top-down mass spectrometry in disease biomarker discovery, proteoform database annotation, and protein function studies.

Research Interests

  • Algorithmic biology
  • Computational proteomics


INFO B419/B519 Introduction to Bioinformatics

INFO B429/B529 Machine Learning in Bioinformatics

INFO B436/B536 Computational Methods for Biomedical Informatics

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