James Stevens, Ph.D.
stevens_james_llilly [dot] com
- Adjunct Professor, Bioinformatics
Dr. Stevens received his PhD in Pharmacology from the University of Minnesota in 1980 and was awarded a PRAT Fellowship from the National Institute of General Medical Sciences at the National Institutes of Health in Bethesda, MD. He was appointed a Senior Staff Fellow in the Bureau of Biologics, FDA in 1983, and in 1986 joined the W. Alton Jones Cell Science Center, Lake Placid, NY, as a Senior Scientist. He was appointed Executive Director of the Center in 1992, serving in that capacity until 1998 when he became a Professor of Pathology at the University of Vermont. He joined Lilly Research Laboratory in 2000.
Dr. Stevens has also served in a number of profession capacities. He was a member of the Board of Directors for Upstate Biotechnology and the Interim Vice President for Research and Development for Argonex Pharmaceuticals. He has also served the Society of Toxicology as President of both the Molecular Biology and Mechanisms Specialty Sections. Dr. Stevens has organized numerous sessions at national meetings, including SOT plenary sessions, and chaired a number of meetings including the Gordon Research Conferences, and is a member of the HESI Board of Trustees. He received the Achievement Award from the Society of Toxicology in 1994 and was elected a Fellow of the American Association for the Advancement of Sciences in 1996.
Dr. Stevens’ research interests are in the areas of predictive and molecular/investigative toxicology and adverse drug reactions. He has studied the role of gene expression in mechanisms of cell injury for over 2 decades and was among the first to adopt gene expression analysis to understand mechanisms of toxicity. He has published over 90 peer reviewed articles.
- Ichimura T, Hung CC, Yang SA, Stevens JL, Bonventre JV. 2004. Kidney Injury Molecule-1: a tissue and urinary biomarker for nephrotoxicant-induced renal injury. American Journal of Physiology, 286:F552-F563.
- Kramer JA, Petit SD, Bertram TA, Car B, Cunningham M, Curtiss SW, Davis JW, Kind C, Lawton M, Nacif JM, Oreffo V, Roman RJ, Sistare FD, Stevens JL, Thompson K, Vickers AE, Wild S, Afshari CA. 2004. Overview of the application of transcription profiling using selected nephrotoxicants for toxicology assessment. Environmental Health Perspectives 112(4):460-64.
- Wei T, Liao B, Ackermann BL, Jolly RA, Eckstein JA, Kulkarni NH, Helvering LM, Goldstein KM, Shou J, Estrem ST, Ryan TP, Colet JM, Thomas CE, Stevens JL, Onyia JE. 2005. Data-driven analysis approach for biomarker discovery using molecular-profiling technologies. Biomarkers. (2-3):153-72.
- Fostel J, Choi D, Zwickl C, Morrison N, Rashid A, Hasan A, Bao W, Richard A, Tong W, Bushel PR, Brown R, Bruno M, Cunningham ML, Dix D, Eastin W, Frade C, Garcia A, Heinloth A, Irwin R, Madenspacher J, Merrick BA, Papoian T, Paules R, Rocca-Serra P, Sansone AS, Stevens J, Tomer K, Yang C, Waters M. 2005. Chemical effects in biological systems-data dictionary (CEBS-DD): a compendium of terms for the capture and integration of biological study design description, conventional phenotypes, and ‘omics data. Toxicological Sciences 88:585-601.
- Asmellash S, Stevens JL, Ichimura T. 2005. Modulating the endoplasmic reticulum stress response with trans-4,5-dihydroxy-1,2-dithiane prevents chemically induced renal injury in vivo. Toxicological Sciences. 88:576-584.
- Stevens, JL. 2006. Future of toxicology-mechanisms of toxicity and drug safety: where do we go from here? Chemical Research in Toxicology 19:1393-401.
- Guo Y, Jolly RA, Halstead BW, Baker TK, Stutz JP, Huffman M, Calley JN, West A, Gao H, Searfoss GH, Li S, Irizarry AR, Qian HR, Stevens JL, Ryan TP. 2007. Underlying mechanisms of pharmacology and toxicity of a novel PPAR agonist revealed using rodent and canine hepatocytes. Toxicological Sciences 96:294-309.
- Fostel JM, Burgoon L, Zwickl C, Lord P, Corton JC, Bushel PR, Cunningham M, Fan L, Edwards SW, Hester S, Stevens J, Tong W, Waters M, Yang C, Tennant R. 2007. Towards a checklist for exchange and interpretation of data from a toxicology study. Toxicological Sciences 99:26-34.
- Stevens JL and Baker TK. 2008. The Future of Drug Safety Testing: Expanding the view and narrowing the focus. Drug Discovery Today, in press
- Ryan TP, Stevens JL, Thomas CE. 2008. Strategic Applications of Toxicogenomics in Early Drug Discovery. Current Opinion in Pharmacology, in press.